There’s a trope in medicine that doctors only have three ways of dealing with cancer: cutting (surgery), burning (radiation), and poisoning (chemotherapy). Oncologists have long sought a fourth path—using the body’s own immune system to attack tumors—but progress has been very, very slow.
Thus, it was surprising to see a headline in the Pittsburgh Post-Gazette last Wednesday that read, “Cancer vaccines may be on the verge of wider use.”
My first thought was, what kind of vaccines are we talking about? My second was, well, if we’re talking about vaccines for treating cancer (as opposed to preventing it), one would be a start.
Lately, there has been a lot of chatter that, by May 1, the U.S. Food and Drug Administration is expected to approve Provenge (sipuleucel-T), a drug for the treatment of metastatic prostate cancer. It would be the first vaccine approved in the United States for the treatment of cancer, and, as such, an important step toward enlisting the immune system’s natural defenses in the fight against a disease that kills over half a million Americans each year.
But don’t expect to find much enlightenment in the Post-Gazette’s article. The piece, by staff writer Mark Roth, gets off to a bad start by reporting that, according to scientists, “we may be on the verge of being able to vaccinate people against cancer in the same way we do with infectious diseases … The first commercial cancer vaccine out of the gate is likely to be sipuleucel-T, a vaccine against prostate cancer being made by Dendreon Corp. of Seattle, Wash.”
This is a bad start for many reasons. First, Roth makes no distinction between vaccines designed to prevent cancer and vaccines designed to treat cancer. The expression “vaccinate against” implies that he is writing about the former, but Provenge is designed to treat cancer, as are most of the other vaccines cited in the article. Thus, sipuleucel-T does not “vaccinate against” prostate cancer, but rather creates an immune response to fight cancer cells that are already present. Moreover, even prevention drugs don’t “vaccinate against cancer,” strictly speaking—they vaccinate against viruses that can cause cancer.
That brings us to the second problem with Roth’s article. “The first commercial cancer vaccine” is already out of the gate and has been for some time. It is a preventative vaccine against the hepatitis B virus (HBV), which can cause liver cancer. The FDA approved it in 1981. There is also Gardasil, a vaccine against two strains of human papillomavirus that can cause cervical cancer, which the FDA approved in 2006. In 2008, the FDA approved Gardasil for use in preventing HPV-associated vulvar and vaginal cancers as well.
According to a useful cancer vaccines fact sheet from the National Cancer Institute, “many scientists believe that microbes cause or contribute to between 15 percent and 25 percent of all cancer diagnosed worldwide each year, with the percentages being lower in developed countries than in developing countries.” But in any story about preventive vaccines, it is important to note that in addition to HBV and HPV, only three other viruses, one bacterium, and two parasites have even been associated with certain types of cancer.
There are currently no vaccines approved in U.S. for the treatment of cancer, and therein lies the third problem with Roth’s article. Even if the FDA gives Provenge the green light this spring, it will likely be awhile before it is fair to say that cancer vaccines are “on the verge of wider use.” Even Cure magazine, which is owned by U.S. Oncology, Inc. (a network whose goal is “to increase patient access to, and advance the delivery of, high quality cancer care in America through our clinical insight and expertise”), recently reported that “cancer vaccine researchers caution that it could be years before clinicians routinely use this immunological approach to treat cancer.”